Take advantage, use Advanced

Enova AdvancedTM Non Diffractive  
Hydrophobic EDoF IOL

Our new A-class product - The Enova AdvancedTM non-diffractive EDoF IOL Available
on our hydrophobic material plattform - Enova®.

Non-diffractive “Light Tailoring Technology“ providing:
  • Excellent visual acuity for far vision.
  • Great visual acutiy for intermediate vision reaching into near vision zone.
  • Monofocal-like halo and glare profile.
Launched on next generation hydrophobic Enova® IOL material platform combining:
  • 100% glistening-free.
  • Dry-packed.
  • Controlled unfolding even in operating room temperature settings.

Take advantage, use Advanced

Sharp far vision1
Strong intermediate
vision1
Near vision effect1
Monofocal-like halo and glare profile1
100% glistening-free material2
Controlled unfolding feature3

1.Data on file. Medical Report MR_EA_230605. VSY Biotechnology Laboratories. 06.2023.

2.Data on file. L. Werner at. al. In vitro study evaluating the tendency of different intraocular lenses to form intraoptical glistenings. Study report. RDR_EGF3_05072020. Utah, USA 07.2020.

3.Data on file. Technical Report TR_EA_200511. VSY Biotechnology Laboratories. 05.2020

Light Tailoring Technology

Discover VSY Biotechnology's groundbreaking "Light tailoring technology" for exceptional optical performance even in 
challenging lighting conditions. Experience the new A-class product, the non-diffractive Enova AdvancedTM EDoF IOL.

Light Tailoring Technology

The unique Light Tailoring Technology uses two structures (LTS 1 and 2) placed in the central 2 mm aperture to broaden and fine-tune the provided light.

  • LTS 1 widens and distributes light beyond the far focus into intermediate and near vision ranges.
  • LTS 2 Fine-tunes light for a more refined intermediate visual acuity and basic near visual acuity.
  • LTS 1 distributes light broadly for EDoF.
  • LTS 2 Fine-tunes the light distribution to strengthen the relevant distances (far, intermediate and basic near).

Light Tailoring Technology

“Light tailoring technology” delivers outstanding distance vision in photopic, mesopic, and scotopic light conditions 
along with excellent intermediate vision.

Light Tailoring Technology Working Principle

  • Light Tailoring Structure 1 provides a broader far and intermediate distribution of light energy.
  • Light Tailoring Structure 2 improves the light distribution for "tailor-made" visual acuity for far, intermediate, and basic near vision.
  • Enova AdvancedTM has a minimal spherical aberration design thanks to its light tailoring structure.

X-Wave Technology Working Principle

  • Transition Element 1 stretches the light for EDoF.*
  • Transition Element 2 shifts the wavefront for maximum energy usage.*

*Tognetto, Daniele, et al. "Profile of a new extended range-of-vision IOL: a laboratory study." Graefe's Archive for Clinical and Experimental Ophthalmology (2022): 1-4. 
Ferrando, Vicente, et al. "Profile of a new extended range-of-vision IOL: comments on the laboratory study by Tognetto et al." Graefe's Archive for Clinical and Experimental Ophthalmology 260.12 (2022): 4021-4022.

Optical Benchmark Results Enova AdvancedTM vs. Acrysof Vivity®

Enova AdvancedTM distributes more light energy to the far vision and thus shows higher
modulation transfer function (MTF) values compared to Acrysof Vivity®.

Measurement Equipment: Lambda PMTF device (Belgium) / In house measurement. Eye Model: ISO Eye Model / with minimal spherical aberration. Samples: Advanced and Vivity lenses with 21 D. Measurement Date: 06.2023

Optical Benchmark Results Enova AdvancedTM vs. Acrysof Vivity®

Enova AdvancedTM has a higher focus on the far foci and thus providing excellent visual acuity even in challenging lighting conditions.

Measurement Equipment: Lambda PMTF device (Belgium) / In house measurement. Eye Model: ISO Eye Model / with minimal spherical aberration. Samples: Advanced and Vivity lenses with 21 D. Measurement Date: 06.2023

Theoretical Defocus Curve Comparison

Enova AdvancedTM EDoF vs. Acrysof Vivity® EDoF vs. Enova® GF3 Monofocal

Compared to Acrysof Vivity®, the theoretical defocus curve values demonstrate excellent far vision without deficiencies in the intermediate range.

Measurement Equipment: Theoretically derived from inhouse MTF measurements [1]. 
Samples: ENOVA GF3, Advanced and Vivity lenses with 21 D. Measurement Date: 06.2023 [1] Alarcon, A., Canovas, C., Rosen, R., Weeber, H., Tsai, L., Hileman, K., & Piers, P. (2016). Preclinical metrics to predict through-focus visual acuity for pseudophakic patients. Biomedical Optics Express, 7(5), 1877. https://doi.org/10.1364/BOE.7.001877

USAF Target Images Enova AdvancedTM vs. Acrysof Vivity®

Enova AdvancedTM EDoF vs. Acrysof Vivity® EDoF vs. Enova® GF3 Monofocal

Measurement Equipment: Lambda PMTF device (Belgium) / In house measurement. Eye Model: ISO Eye Model / with minimal spherical aberration. Samples: Advanced and Vivity lenses with 21 D. Measurement Date: 06.2023

Measurement Equipment: Lambda PMTF device (Belgium) / In house measurement. Eye Model: ISO Eye Model / with minimal spherical aberration. Samples: Advanced and Vivity lenses with 21 D. Measurement Date: 06.2023

100% Glistening Free IOL Material

The Enova® IOL Material is the first 100% glistening-free hydrophobic acrylic IOL that does not require pre-hydration and storage in saline solution!

100% Glistening-Free
Next Generation Hydrophobic
Dry-Packed

The Enova AdvancedTM EDoF IOL is dry-packed and boasts exceptional optical and mechanical properties.

The glistening study was performed at the Intermountain Ocular Research Center (Mamalis/Werner Laboratory), John A.Moran Eye Center, University of Utah and the unique composition of Enova® hydrophobic acrylic IOL shows zero glistening and haze compared with other IOLS.

Outstanding Biomechanical Properties

A polymer's Glass transition temperature is reached when the polymer changes from a rigid material to a soft material. Having a Tg of -2.0°C, all IOLs with the unique Enova® material undergo a gentle and controlled unfolding process that occurs below standard operating room temperatures.

Thus, no warming or special pre-conditioning is required.

Technical Features

Early Multi Center Clinical Results

Number of eyes n=92 
Number of patients n=63

Conclusion

The first post-operative visual acuity results are extremely positive regarding the far and intermediate vision and even basic reading capabilities when it comes to the near vision. Refractive errors were in an acceptable range of -0.50 D and +0.50 D. No glistening was observed.
IOL Centralization is very good. No decentralization and tilt were observed.
No adverse event was reported. Early patient satisfaction rates were excellent.